| Date | Artist - Title | Weeks at #1 |
|---|---|---|
2000 Number One Songs | ||
| – | Westlife - I Have A Dream / Seasons In The Sun | 4 |
| – | Manic Street Preachers - The Masses Against The Classes | 1 |
| – | Britney Spears - Born To Make You Happy | 1 |
| – | Gabrielle - Rise | 2 |
| – | Oasis - Go Let It Out | 1 |
| – | All Saints - Pure Shores | 2 |
| – | Madonna - American Pie | 1 |
| – | Chicane feat. Bryan Adams - Don't Give Up | 1 |
| – | Geri Halliwell - Bag It Up | 1 |
| – | Melanie C with Lisa 'Left Eye' Lopes - Never Be The Same Again | 1 |
| – | Westlife - Fool Again | 1 |
| – | Craig David - Fill Me In | 1 |
| – | Fragma - Toca's Miracle | 2 |
| – | Oxide and Neutrino - Bound 4 Da Reload (Casualty) | 1 |
| – | Britney Spears - Oops!... I Did It Again | 1 |
| – | Madison Avenue - Don't Call Me Baby | 1 |
| – | Billie Piper - Day And Night | 1 |
| – | Sonique - It Feels So Good | 3 |
| – | Black Legend - You See The Trouble With Me | 1 |
| – | Kylie Minogue - Spinning Around | 1 |
| – | Eminem - The Real Slim Shady | 1 |
| – | Corrs - Breathless | 1 |
| – | Ronan Keating - Life Is A Rollercoaster | 1 |
| – | Five and Queen - We Will Rock You | 1 |
| – | Craig David - 7 Days | 1 |
| – | Robbie Williams - Rock DJ | 1 |
| – | Melanie C - I Turn To You | 1 |
| – | Spiller - Groovejet (If This Ain't Love) | 1 |
| – | Madonna - Music | 1 |
| – | A1 - Take On Me | 1 |
| – | Modjo - Lady (Hear Me Tonight) | 2 |
| – | Mariah Carey and Westlife - Against All Odds (Take a Look at Me Now) | 2 |
| – | All Saints - Black Coffee | 1 |
| – | U2 - Beautiful Day | 1 |
| – | Steps - Stomp | 1 |
| – | Spice Girls - Holler / Let Love Lead The Way | 1 |
| – | Westlife - My Love | 1 |
| – | A1 - Same Old Brand New You | 1 |
| – | LeAnn Rimes - Can't Fight The Moonlight | 1 |
| – | Destiny's Child - Independent Women Part 1 | 1 |
| – | S Club 7 - Never Had A Dream Come True | 1 |
| – | Eminem - Stan | 1 |
| – | Bob The Builder - Can We Fix It? | 3 |
43 different songs hit number one in the UK during 2000.
