| Date | Artist - Title | Weeks at #1 |
|---|---|---|
2010 Number One Songs | ||
| – | Joe McElderry - The Climb | 1 |
| – | Lady Gaga - Bad Romance | 2 (1) |
| – | Iyaz - Replay | 2 |
| – | Owl City - Fireflies | 3 |
| – | Helping Haiti - Everybody Hurts | 2 |
| – | Jason Derulo - In My Head | 1 |
| – | Tinie Tempah - Pass Out | 2 |
| – | Lady Gaga feat. Beyonce - Telephone | 2 |
| – | Scouting for Girls - This Ain't a Love Song | 2 |
| – | Usher feat. will.i.am - OMG | 1 |
| – | Diana Vickers - Once | 1 |
| – | Roll Deep feat. Jodie Connor - Good Times | 3 |
| – | B.o.B feat. Bruno Mars - Nothin' on You | 1 |
| – | Dizzee Rascal - Dirtee Disco | 1 |
| – | David Guetta and Chris Willis feat. Fergie and LMFAO - Gettin' Over You | 1 |
| – | Dizzee Rascal and James Corden - Shout For England | 2 |
| – | Katy Perry feat. Snoop Dogg - California Gurls | 2 |
| – | JLS - The Club Is Alive | 1 |
| – | B.o.B feat. Hayley Williams - Airplanes | 1 |
| – | Yolanda Be Cool and DCUP - We No Speak Americano | 1 |
| – | The Wanted - All Time Low | 1 |
| – | Ne-Yo - Beautiful Monster | 1 |
| – | Flo Rida feat. David Guetta - Club Can't Handle Me | 1 |
| – | Roll Deep - Green Light | 1 |
| – | Taio Cruz - Dynamite | 1 |
| – | Olly Murs - Please Don't Let Me Go | 1 |
| – | Alexandra Burke feat. Laza Morgan - Start Without You | 2 |
| – | Bruno Mars - Just the Way You Are | 2 (1) |
| – | Tinie Tempah feat. Eric Turner - Written in the Stars | 1 |
| – | Cee Lo Green - F**k You! (Forget You) | 2 |
| – | Bruno Mars - Just the Way You Are | 2 (1) |
| – | Cheryl Cole - Promise This | 1 |
| – | Rihanna - Only Girl (In The World) | 2 |
| – | JLS - Love You More | 1 |
| – | The X Factor Finalists 2010 - Heroes | 2 |
| – | Black Eyed Peas - The Time (Dirty Bit) | 1 |
| – | Matt Cardle - When We Collide | 3 |
36 different songs hit number one in the UK during 2010.
